Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus

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Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus.

Oxytocin (Oxt) is released in various hypothalamic and extrahypothalamic brain areas in response to anxiogenic stimuli to regulate aspects of emotionality and stress coping. We examined the anxiolytic action of Oxt in the hypothalamic paraventricular nucleus (PVN) while appraising if Oxt recruits GABA neurons to inhibit the behavioral, hormonal, and neuronal response to stress in female prairie...

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ژورنال

عنوان ژورنال: Psychoneuroendocrinology

سال: 2016

ISSN: 0306-4530

DOI: 10.1016/j.psyneuen.2015.09.017